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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1035908Generated: October 30, 2026

Tetrahydro-4H-pyran-4-one → (S)-tert-butyl 1-(tetrahydro-2H-pyran-4-yl)piperidin-3-ylcarbamate

https://huagongshe.com/reaction/1035908

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydro-4H-pyran-4-oneHCID 121599—
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant4'-Chlorobiphenyl-2-carbaldehydeHCID 1393689—
Product(S)-tert-butyl 1-(tetrahydro-2H-pyran-4-yl)piperidin-3-ylcarbamateHCID 67126493—

Reaction Steps

The title compound was prepared by substituting (S)-tert-butyl piperidin-3-ylcarbamate for tert-butyl piperazine-1-carboxylate and dihydro-2H-pyran-4(3H)-one for 4′-chlorobiphenyl-2-carboxaldehyde in EXAMPLE 1A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08546399B2
Source datasetuspto-grants-2013_10
ORD IDord-6b8b522c73b84a88b17286b72c473aee
Source noteuspto-grants-2013_10