反应详情

To a solution of EXAMPLE 265A (15.88 g) in ethanol (300 mL) was added but-3-enone (3.89 g). The mixture was stirred at reflux overnight. Then acetic acid (30 mL) was added to the mixture which was stirred at reflux again overnight. The mixture was then concentrated under vacuum and the residue was diluted with ethyl acetate (400 mL) and washed with water and brine and dried over Na2SO4. After filtration and evaporation of the solvent, column purification gave the title compound.

1. temperatureat reflux overnight
2. stirringwas stirred
3. temperatureat reflux again overnight
4. concentrationThe mixture was then concentrated under vacuum
5. additionthe residue was diluted with ethyl acetate (400 mL)
6. washwashed with water and brine
7. dry with materialdried over Na2SO4
8. filtrationAfter filtration and evaporation of the solvent, column purification