HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-((1-Fluoro-4-oxocyclohexyl)methoxy)-3-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-((4'-Fluorospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-4'-yl)methoxy)-3-nitrobenzenesulfonamide | HCID 67127181 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-((1-Fluoro-4-oxocyclohexyl)methoxy)-3-nitrobenzenesulfonamide | HCID 67126764 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of EXAMPLE 363A (860 mg) in ethanol (30 mL) was added concentrated HCl (10 mL) and the mixture was stirred at 100° C. for 3 hours. The mixture was neutralized with solid Na2CO3 and extracted with dichloromethane (300 mL) and washed with aqueous NaHCO3, water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546399B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-e5f36fc1720245e3aac7aa6bf58fada1 |
| Source note | uspto-grants-2013_10 |