反应详情

To a solution of 1,3-dibenzylpyrrolidine-3-carboxylic acid ethyl ester (Example A18e, 13.1 g, 41 mmol) in 250 mL of methanol is added 2N NaOH (46 mL, 92 mmol) and the reaction is heated to reflux for 24 hours. The solution is cooled, concentrated, redissolved in water and extracted with ether. The pH of the aqueous layer is adjusted to 7 and the precipitated solid is collected, to give 9.3 g of the title compound, MS EI+: m/z 296 (MH+), mp 209–210° C.

1. temperaturethe reaction is heated
2. temperatureto reflux for 24 hours
3. temperatureThe solution is cooled
4. concentrationconcentrated
5. dissolutionredissolved in water
6. extractionextracted with ether
7. customthe precipitated solid is collected