Potassium Phosphate, Tribasic → US10251893, Cpd 194

Participants

Reaction Conditions

Reaction Steps

To a reaction vial was added N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(6-chloro-5-fluoropyridin-3-yl)acetamide 190-6 (66 mg, 0.17 mmol), 2-fluoropyridin-4-ylboronic acid 193-1 (35 mg, 0.25 mmol), Pd(OAc)2 (2 mg, 0.009 mmol), S-Phos (7 mg, 0.017 mmol) and K3PO4 (108 mg, 0.51 mmol) in 2-butanol (0.3 mL). The reaction was heated to 100° C. and stirred for 2 hours. The reaction was cooled down to room temperature and then diluted to DMSO. The reaction mixture was filtered and the filtrate was purified by reverse-phase HPLC to give N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2′,3-difluoro-2,4′-bipyridin-5-yl)acetamide 194. MS m/z 453.1 (M+1).

Provenance & Evidence