反应详情

To a suspension of 6-amino-5-(2,2-diethoxy-ethyl)-2-mercapto-pyrimidin-4-ol (1.19 g, 4.6 mmol) in water (50 ml) was added Raney nickel (Aldrich Raney 2800 nickel, 4.8 ml). The mixture was heated at reflux for 1 hour, and then the hot solution was filtered through Celite®. The nickel residue was washed with further water (100 ml), and these washings were filtered through Celite. The aqueous filtrate was evaporated to dryness to yield the title product (0.747 g, 71%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 hour
3. filtrationthe hot solution was filtered through Celite®
4. washThe nickel residue was washed with further water (100 ml)
5. filtrationthese washings were filtered through Celite
6. customThe aqueous filtrate was evaporated to dryness