1-Methylpiperazine → HCID 68528916, compound

Participants

Reaction Steps

A solution of the product from Example 8C (0.048 g, 0.12 mmol) and N-methylpiperazine (0.25 g, 0.25 mmol) in acetonitrile (1 mL) was heated in a microwave at 160° C. for 1 hour. The reaction mixture was partitioned in dichloromethane/water, the organic layer was separated, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel, eluting with 5% methanol/dichloromethane/1% ammonium hydroxide to yield the title compound: 1H NMR (300 MHz, DMSO-d6) δ 7.84 (m, 1 H), 5.96 (m, 2 H), 3.76 (s, 3 H), 3.07 (m, 4 H), 2.93 (t, J=6.27 Hz, 2 H), 2.59 (m, 2 H), 2.43 (m, 4 H), 2.22 (s, 3 H), 1.90 (m, 2 H); MS (ESI+) m/z 314 (M+H)+.

Provenance & Evidence