Ethanol → HCID 46196262, compound

Participants

Reaction Steps

The compound was prepared in a manner similar as to that described above using (R)-4-[6-(4-isopropyl-cyclohexyloxy)-naphthalen-2-yl]-4-methyl-oxazolidin-2-one (200 mg, 0.0005 mol), ethanol (2.2 g, 0.049 mol), 4.2 M lithium hydroxide, monohydrate in water (2.1 mL, 0.0090 mol) to give 56 mg of the desired compound as a yellow brown solid (30%). ESI-MS: 325 (M−16)+. 1H NMR (400 MHz, CDCl3) δ=7.94-7.61 (m, 3H), 7.50 (d, J=8.5 Hz, 1H), 7.23-7.05 (m, 2H), 4.67 (br. s., 1H), 4.33-4.17 (m, 1H), 3.84-3.51 (m, 2H), 2.35-1.75 (m, 4H), 1.68-1.08 (m, 10H), 1.01-0.68 (m, 6H).

Provenance & Evidence