Ethanol → HCID 46196243, compound

Participants

Reaction Steps

The compound was prepared in a manner similar as to that described above using (R)-4-[6-(4-sec-Butyl-cyclohexyloxy)-naphthalen-2-yl]-4-methyl-oxazolidin-2-one (200 mg, 0.0005 mol), ethanol (2.2 g, 0.049 mol) and 4.2 M lithium hydroxide, monohydrate in water (2.1 mL, 0.0090 mol) to give 152 mg of the desired product as a white solid (50%). ESI-MS: 339 (M−16)+. 1H NMR (400 MHz, DMSO-d6) δ=8.30 (s, 1H), 7.88 (s, 1H), 7.75 (d, J=8.8 Hz, 1H), 7.71-7.56 (m, 1H), 7.24 (d, J=2.0 Hz, 1H), 7.12 (dd, J=2.3, 8.8 Hz, 1H), 4.70 (d, J=5.8 Hz, 1H), 4.40-4.28 (m, 1H), 3.55-3.41 (m, 2H), 2.26-1.07 (m, 12H), 0.94-0.79 (m, 3H)

Provenance & Evidence