HCID 178447443, compound → HCID 178447440, compound

HRID 1036474Notes

Reaction equation

C([C@H]1CC[C@H](OC2C=C3C(=CC=2)C=C(C([N+]([O-])=O)(C)CCC(O)=O)C=C3)CC1)(C)(C)C.[C:32]([C@H:36]1[CH2:41][CH2:40][C@H:39]([O:42][C:43]2[C:44]([C:64]([F:67])([F:66])[F:65])=[C:45]3[C:50](=[CH:51][CH:52]=2)[CH:49]=[C:48]([C:53]([N+:61]([O-:63])=[O:62])([CH3:60])[CH2:54][CH2:55][C:56]([O:58]C)=[O:57])[CH:47]=[CH:46]3)[CH2:38][CH2:37]1)([CH3:35])([CH3:34])[CH3:33]>>[C:32]([C@H:36]1[CH2:37][CH2:38][C@H:39]([O:42][C:43]2[C:44]([C:64]([F:65])([F:66])[F:67])=[C:45]3[C:50](=[CH:51][CH:52]=2)[CH:49]=[C:48]([C:53]([N+:61]([O-:63])=[O:62])([CH3:60])[CH2:54][CH2:55][C:56]([OH:58])=[O:57])[CH:47]=[CH:46]3)[CH2:40][CH2:41]1)([CH3:33])([CH3:34])[CH3:35]

Participants

Reactant 2

HCID 178447443HCID 178447443, compound

HCID 178500160HCID 178500160, compound

Product 1

HCID 178447440HCID 178447440, compoundYield 10%

Procedure

4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitropentanoic acid was synthesized as per 4-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-4-nitropentanoic acid (Example 206) in 10% yield using methyl 4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitropentanoate as starting material.

Sources & evidence

ORD record: ord-4463a25ff0b143a99d408f7b8bd5cda3
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546359B2

Reaction notes

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