HRID1036474

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(CCC(=O)O)(c1ccc2cc(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2c1)[N+](=O)[O-]

HCID178447443

未命名化合物

结构：COC(=O)CCC(C)(c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2c1)[N+](=O)[O-]

HCID178500160

未命名化合物

PRODUCTS

生成物

结构：CC(CCC(=O)O)(c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2c1)[N+](=O)[O-]

HCID178447440

未命名化合物

收率 10%

PROCEDURE

实验过程

4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitropentanoic acid was synthesized as per 4-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-4-nitropentanoic acid (Example 206) in 10% yield using methyl 4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitropentanoate as starting material.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4463a25ff0b143a99d408f7b8bd5cda3
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546359B2
来源说明: uspto-grants-2013_10

反应 SMILES

C([C@H]1CC[C@H](OC2C=C3C(=CC=2)C=C(C([N+]([O-])=O)(C)CCC(O)=O)C=C3)CC1)(C)(C)C.[C:32]([C@H:36]1[CH2:41][CH2:40][C@H:39]([O:42][C:43]2[C:44]([C:64]([F:67])([F:66])[F:65])=[C:45]3[C:50](=[CH:51][CH:52]=2)[CH:49]=[C:48]([C:53]([N+:61]([O-:63])=[O:62])([CH3:60])[CH2:54][CH2:55][C:56]([O:58]C)=[O:57])[CH:47]=[CH:46]3)[CH2:38][CH2:37]1)([CH3:35])([CH3:34])[CH3:33]>>[C:32]([C@H:36]1[CH2:37][CH2:38][C@H:39]([O:42][C:43]2[C:44]([C:64]([F:65])([F:66])[F:67])=[C:45]3[C:50](=[CH:51][CH:52]=2)[CH:49]=[C:48]([C:53]([N+:61]([O-:63])=[O:62])([CH3:60])[CH2:54][CH2:55][C:56]([OH:58])=[O:57])[CH:47]=[CH:46]3)[CH2:40][CH2:41]1)([CH3:33])([CH3:34])[CH3:35]