HCID 178445729, compound → HCID 178445753, compound

Participants

Reaction Steps

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(pyrimidin-5-yl)naphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 48% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(pyrimidin-5-yl)naphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z 417.28 [M−16]+. 1H NMR (MeOD) δ: 9.21 (s, 1H), 8.79 (s, 2H), 7.99-8.05 (m, 2H), 7.59 (dd, J=9.0, 2.0 Hz, 1H), 7.52 (d, J=9.3 Hz, 1H), 7.42 (d, J=9.0 Hz, 1H), 4.26-4.35 (m, 1H), 3.73 (d, J=10.8 Hz, 1H), 3.69 (d, J=10.8 Hz, 1H), 2.08-2.15 (m, 2H), 1.80-1.87 (m, 2H), 1.52 (s, 3H), 1.14-1.23 (m, 4H), 0.96-1.06 (m, 1H), 0.88 (s, 9H)

Provenance & Evidence