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HRID1036522

反应详情

EQUATION

反应方程式

HRID 1036522 的结构方程式

REACTANTS

反应物

4
结构：CC(C)OC(=O)/N=N/C(=O)OC(C)C
HCID5363146

Diisopropyl azodicarboxylate

C8H14N2O4

结构：CCOC(=O)/N=N/C(=O)OCC
HCID5462977

(E)-Diethyl azodicarboxylate

C6H10N2O4

结构：CCCCCC1CCC(Oc2ccc3cc([C@]4(C)COC(=O)N4)ccc3c2)CC1
HCID67413569

未命名化合物

结构：C[C@](N)(CO)c1ccc2cc(O[C@H]3CC[C@@H](C(F)(F)F)CC3)ccc2c1
HCID178464725

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCC1CCC(Oc2ccc3cc([C@@](C)(N)CO)ccc3c2)CC1
HCID46196192

未命名化合物

收率 35%

PROCEDURE

实验过程

(R)-2-Amino-2-[6-(4-pentyl-cyclohexyloxy)-naphthalen-2-yl]-propan-1-ol was synthesized as per (R)-2-Amino-2-[6-(cis-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propan-1-ol (Example 259) in 35% yield (and 21% recovered starting material) using (R)-4-Methyl-4-[6-(4-pentyl-cyclohexyloxy)-naphthalen-2-yl]-oxazolidin-2-one as starting material. Note that the starting material contained 20% impurity (mixture of reduced DIAD, reduced DEAD).