Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

2-[2-Amino-5-(3-hydroxy-phenylethynyl)-pyrimidin-4-yl]-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (22 mg, 0.048 mmol) was suspended in dry dioxane (1 mL) under nitrogen atmosphere and 4 N HCl solution in dioxane (0.120 mL, 0.48 mmol, 10 eq) was added. After stirring for 45 minutes at room temperature the suspension was evaporated to dryness, taken up with methanol and evaporated to dryness (3×2 mL). The residue was diluted with ethyl ether and evaporated to dryness (3×2 mL). The desired product was obtained as hydrochloride (21 mg, yellow solid).

Provenance & Evidence