HCID 67286074, compound → HCID 49842162, compound

Participants

Reaction Steps

A suspension of 2-{2-[(E)-2-(3-Chloro-phenyl)-vinyl]-pyrimidin-4-yl}-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (0.050 g, 0.107 mmol) in 4M HCl/dioxane (2.0 ml) was stirred at room temperature for 1 h. The solvent was removed under vacuum and the product was purified by crystallisation from methanol, yielding 2-{2-[(E)-2-(3-Chloro-phenyl)-vinyl]-pyrimidin-4-yl}-1-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one as a yellow solid (0.015 g, 0.041 mmol, 38%).

Provenance & Evidence