HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → HCID 54124074, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Ethyl 3-(2-fluorophenyl)-3-oxopropanoate | HCID 296342 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 54124074 | HCID 54124074 | — |
Reaction Steps
A mixture of ethyl 3-(2-fluorophenyl)-3-oxopropanoate (14.29 g, 68.0 mmol) and DMF-DMA (12.15 g, 0.102 mol, 1.5 eq.) in toluene (50 mL) was refluxed for 2 hours and concentrated to give 3-dimethylamino-2-(2-fluoro-benzoyl)-acrylic acid ethyl ester as a red oil in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546414B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-fd9adbfcc1984775a5aba24e441d2a13 |
| Source note | uspto-grants-2013_10 |