HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-Benzyl4-(2-chlorophenyl)-N-isopropyl-2-morpholinopyrimidine-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isopropylbenzylamine | HCID 66024 | — |
| Reactant | 4-(2-Chlorophenyl)-2-morpholino pyrimidine-5-carboxylic acid | HCID 21712446 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-Benzyl4-(2-chlorophenyl)-N-isopropyl-2-morpholinopyrimidine-5-carboxamide | HCID 11690962 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
In a microwave tube was added 1 eq. of 4-(2-chlorophenyl)-2-morpholino pyrimidine-5-carboxylic acid (80 mg), 1.1 eq. of isopropyl benzylamine (43 mL), 2.5 eq. of triethylamine (80 mL) and 1.2 eq. of BtSO2Me in 4 mL of dioxane. The reaction mixture was heated to 160° C./300 W for 1200 sec. The crude product was purified by prep HPLC. ES+=451.0. NMR confirmed the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546414B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-08cd0a93aed446c1b3e5a93e8a5aabbb |
| Source note | uspto-grants-2013_10 |