反应详情

To a solution of methyl [1-((2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(4-fluorophenyl)sulfonyl]amino}butyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]acetate (1.2 g, 2.2 mmol) in dichloromethane (40 mL) was added 1 M TBAF (4.8 mL, 2.2 equiv.). After a period of 0.5 h the reaction mixture was quenched with 25% aqueous ammonium acetate, the organic phase was separated, dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified on combiflash (20% ethyl acetate in hexane to 100% ethyl acetate) to provide 849 mg of the title compound.

1. customAfter a period of 0.5 h the reaction mixture was quenched with 25% aqueous ammonium acetate
2. customthe organic phase was separated
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated under reduced pressure
6. customThe residue was purified on combiflash (20% ethyl acetate in hexane to 100% ethyl acetate)