Triacetoxyperiodinane → Methyl [1-((2R)-2-{[(4-fluorophenyl)sulfonyl]amino}-4-oxobutyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]acetate

Participants

Reaction Steps

To a solution of methyl [1-((2R)-2-{[(4-fluorophenyl)sulfonyl]amino}-4-hydroxybutyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]acetate (0.89 g, 1.9 mmol) in dichloromethane (16 mL) was added Dess-Martin reagent (0.99 g, 2.3 mmol, 1.2 equiv.). After a period of 45 min. the reaction mixture was purified directly by combiflash (20% ethyl acetate in hexane to 100% ethyl acetate) to give 697 mg of the title compound.

Provenance & Evidence