Tetrahydrofuran → HCID 86672864, compound

Participants

Reaction Steps

The procedure described in stage 2.4 is followed, starting with 0.150 g (0.52 mmol) of 5-bromo-2-(2-fluorophenyl)pyrazolo[1,5-a]pyridine obtained in stage 7.1, 0.092 g (0.61 mmol) of 3-formylphenylboronic acid, 0.502 g (1.54 mmol) of caesium carbonate and 0.042 g (0.050 mmol) of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) in 5 ml of a 9/1 mixture of tetrahydrofuran and water. After chromatography on silica gel, elution being carried out with a mixture of cyclohexane and ethyl acetate (8/2), 0.130 g (79%) of the expected product is obtained in the form of a beige powder.

Provenance & Evidence