HCID 86672864, compound → HCID 86672863, compound

Participants

Reaction Steps

The procedure described in stage 2.5 is followed, starting with 0.125 g (0.40 mmol) of 3-[2-(2-fluorophenyl)pyrazolo[1,5-a]pyridin-5-yl]benzaldehyde obtained in stage 7.2, in solution in 15 ml of tetrahydrofuran, followed by addition of 3.50 ml (1.75 mmol) of an ethynylmagnesium bromide solution (0.5M in tetrahydrofuran) and after chromatography on silica gel, elution being carried out with a mixture of cyclohexane and ethyl acetate (8/2), 0.112 g (82%) of the expected product is obtained in the fatm of a beige powder.

Provenance & Evidence