反应详情

A mixture comprising tert-butyl (2R)-3-(benzyloxy)-1-(2-methyl-1-oxo-4-phenyl-2,7-diazaspiro[4.5]decan-7-yl)-1-oxopropan-2-ylcarbamate (500 mg, 0.959 mmol) and TFA (2.215 ml, 28.8 mmol) in DCM (5 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated in vacuo. The crude was then diluted with DCM (10 mL) and washed with a saturated solution of sodium bicarbonate (10 mL). The aqueous phase was further extracted with DCM (3×10 mL). The combined organic portions were dried (MgSO4), and concentrated under reduced pressure to afford the title compound. No purification was performed on the title compound.

1. concentrationThe reaction mixture was concentrated in vacuo
2. additionThe crude was then diluted with DCM (10 mL)
3. washwashed with a saturated solution of sodium bicarbonate (10 mL)
4. extractionThe aqueous phase was further extracted with DCM (3×10 mL)
5. dry with materialThe combined organic portions were dried (MgSO4)
6. concentrationconcentrated under reduced pressure