反应详情

A solution comprising tert-butyl 2-methyl-1-oxo-3-phenyl-2,6-diazaspiro[3.5]nonane-6-carboxylate (1.2 g, 3.63 mmol) and TFA (1.399 ml, 18.16 mmol) in DCM (20 ml) was stirred at RT for 4 days. The reaction mixture was concentrated in vacuo and the resulting crude product was dissolved with methanol (5 ml) and passed through a 10 g SCX-2 cartridge. The product was eluted with 2M NH3 in methanol (70 ml) and the relevant fractions were combined and concentrated in vacuo to afford the title compound as a yellow oil;

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionthe resulting crude product was dissolved with methanol (5 ml)
3. washThe product was eluted with 2M NH3 in methanol (70 ml)
4. concentrationconcentrated in vacuo