HCID 67203337, compound → HCID 67202315, compound

Participants

Reaction Steps

To a solution of 1-benzyloxy-2-fluoro-4-(2-methylsulfonyl-ethyl)-benzene (1.5 g, 4.87 mmol) in MeOH (25 mL) was added Pd/C (50 mg). The reaction was stirred under H2 (1 atm) for 3 hours. The solid material was filtrated off and the filtrate was concentrated under vacuum to afford the desired compound (981 mg, 92.4%) as a yellowish solid. The crude compound was used for the next step without further purification. 1H NMR (400 MHz, DMSO-d6) δ 9.73 (s, 1H), 7.14˜7.11 (m, 1H), 6.94˜6.87 (m, 2H), 3.43˜3.37 (m, 2H), 2.98 (s, 3H), 2.95˜2.91 (m, 2H). LCMS 228.2 [MH+].

Provenance & Evidence