2-Nitrobenzaldehyde → 4-[(2-Nitrophenyl)methylideneamino]benzonitrile

Participants

Reaction Steps

The mixture of 4-aminobenzonitrile (20 g, 0.17 mol) and 2-nitrobenzaldehyde (28.2 g, 0.17 mol) in anhydrous ethanol was heated to reflux for 3 h. The reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure. The residue was washed with diethyl ether to give 4-(2-nitrobenzylideneamino)benzonitrile as yellow solid (33.7 g, yield 79.3%) LC/MS m/e obsd. (ESI+) [(M+H)+] 252.10.

Provenance & Evidence