Pyridine → HCID 56956241, compound

Participants

Reaction Steps

To a solution of 2-(2-aminophenyl)-4,4-dimethyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile (100 mg, 0.36 mmol) and pyridine (0.12 mL, 1.44 mmol) in anhydrous dichloromethane was added methanesulfonyl chloride (41.3 mg, 0.36 mmol) at ice-bath. After addition, the resulting mixture was stirred at room temperature for 3 h. The reaction mixture was diluted with water, and extracted with dichloromethane. The combined organic layer was dried over anhydrous sodium sulfate, concentrated. The residue was purified by prepared HPLC to give N-[2-(6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-methanesulfonamide as white solid. LC/MS m/e obsd. (ESI+) [(M+H)+] 356.20.

Provenance & Evidence