Benzenesulfonyl chloride → HCID 56967003, compound

Participants

Reaction Steps

To a stirred solution of 2-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-2-yl)aniline (100 mg, 0.35 mmol) in dichloromethane (5 mL) was added triethylamine (100 mg) and benzenesulfonyl chloride (60.2 mg, 0.35 mmol) at ice-bath. The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was washed with water. The aqueous layer was extracted with dichloromethane. The combined organic layer was washed by brine, dried over anhydrous sodium sulfate, concentrated in vacuo. The residue was purified by HPLC to give N-[2-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-benzenesulfonamide LC/MS m/e obsd. (ESI+) [(M+H)+] 427.20.

Provenance & Evidence