反应详情

A mixture of 4-(trifluoromethyl)aniline (5 g) and 2-nitrobenzaldehyde (5.2 g) in anhydrous ethanol was heated to reflux for 3 h; the reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure. The residue was washed with diethyl ether and petro-ether to give N-(2-nitrobenzylidene)-4-(trifluoromethyl)aniline as yellow solid (6.6 g, yield 72.3%). LC/MS m/e obsd. (ESI+) [(M+H)+] 295.1.

1. temperaturewas heated
2. temperatureto reflux for 3 h
3. customThe solvent was removed under reduced pressure
4. washThe residue was washed with diethyl ether and petro-ether