Pyridine → HCID 56966282, compound

Participants

Reaction Steps

To a round bottom flask, benzenesulfonyl chloride (83 mg, 0.54 mmol) was added dropwise a mixture of 2-(3-amino-phenyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile (100 mg, 0.36 mmol) and pyridine (45 mg, 0.54 mmol) in dichloromethane (5 mL). The resultant mixture was allowed to stir overnight. The reaction mixture was washed by water, dried over magnesium sulfate. Filtered and concentrated to provide the crude product. It was purified by column chromatography (silica gel, petroleum ether:ethyl acetate=5:1) to afford N-[3-(6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-benzenesulfonamide as off-white solid (70 mg, yield: 46.5%). MS (ESI+APCI) M+1=418.2.

Provenance & Evidence