2-Fluorobenzenesulphonyl chloride → HCID 56966428, compound

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Reaction Steps

3-(6-Chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamine (150 mg, 0.53 mmol) and the 2-fluoro-benzenesulfonyl chloride (92 mg, 0.63 mmol) was dissolved in pyridine (5 mL). The mixture was stirred at room temperature overnight. The solvent was removed and the residue was purified on column chromatography using petroleum ether/ethyl acetate=5:1 as eluent to afford N-[3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-2-fluoro-benzenesulfonamide (113 mg, yield: 44%) as yellow solid. MS (ESI+APCI) M+1=445.1.

Provenance & Evidence