Pyridine → HCID 56966433, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-Chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-benzenesulfonyl chloride (234 mg, 0.63 mmol) was dissolved in dichloromethane (5 ml). Pyridine (5 ml) was added to the mixture. The resulting solution was cooled to 0° C., and methylamine hydrochloride (64 mg, 0.95 mmol) was added. The mixture was stirred at room temperature for 2 h. Solvent was removed and the residue was purified on Thin layer chromatography using petroleum ether/ethyl acetate=3:1 as eluent to afford 3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-N-methyl-benzenesulfonamide as white solid (100 mg, yield: 40%). MS (ESI+APCI) M+1=395.1.

Provenance & Evidence