Pyridine → HCID 56966500, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-Chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-benzenesulfonyl chloride (204 mg 0.55 mmol) was dissolved in dichloromethane (5 mL). Pyridine (5 mL) was added to the mixture and cooled to 0° C. 4-fluoro-phenylamine (61 mg, 0.55 mmol) was added. The mixture was stirred at room temperature for 2 h. Solvent was removed and the residue was purified on thin layer chromatography using petroleum ether/ethyl acetate=3:1 as eluent to afford 3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-N-(4-fluoro-phenyl)-benzenesulfonamide as white solid (89 mg, 37% yield). MS (ESI+APCI) M+1=445.1.

Provenance & Evidence