Pyridine-3-sulfonyl chloride → HCID 56966501, compound

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Reaction Steps

3-(6-Chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamine (150 mg, 0.53 mmol) and pyridine-3-sulfonyl chloride (102 mg, 0.63 mmol) were dissolved in pyridine (5 mL). The mixture was stirred at room temperature overnight. The solvent was removed and the residue was purified on column chromatography using petroleum ether/ethyl acetate=5:1 as eluent to afford pyridine-3-sulfonic acid [3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide (73 mg, yield: 39%) as yellow solid. MS (ESI+APCI) M+1=357.2.

Provenance & Evidence