3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 46833795, compound

HRID 1037000Notes

Reaction equation

HRID 1037000 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[S:13][C:12]([C:14]([N:16]3[CH2:20][C:19](=[O:21])[NH:18][CH2:17]3)=[O:15])=[CH:11][C:10]=2[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1SC(C(N2CC(=O)NC2)=O)=CC=1C1C=CC=C(Cl)C=1.[F:50][C:51]([F:63])([F:62])[O:52]C1C=C(B(O)O)C=CC=1>>[Cl:28][C:24]1[CH:23]=[C:22]([C:10]2[CH:11]=[C:12]([C:14]([N:16]3[CH2:20][C:19](=[O:21])[NH:18][CH2:17]3)=[O:15])[S:13][C:9]=2[C:4]2[CH:3]=[CH:2][CH:7]=[C:6]([O:52][C:51]([F:63])([F:62])[F:50])[CH:5]=2)[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 46833793HCID 46833793, compoundHCID 58066752HCID 58066752, compound

Product 1

HCID 46833795HCID 46833795, compound

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 5 starting with 70.0 mg (0.15 mmol) of the compound from Example 16A and 45.1 mg (0.22 mmol) of 3-(trifluoromethoxy)phenylboronic acid. 26.7 mg (39% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-c27c08d14dd94031acfa0e164dfa0dc8
Source dataset
uspto-grants-2013_10
Patent number
US08546438B2

Reaction notes

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