Hydrochloric Acid → HCID 67247370, compound

Participants

Reaction Steps

A solution of methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)indolizine-8-carboxylate (30 mg, 0.066 mmol) and NaOH (14 mg, 0.33 mmol) in H2O-THF (1:1, 10 mL) was stirred at rt for 3 h. The mixture was acidified with 2 N HCl and extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by prep-TLC to give 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid (10 mg; yield 34%) as a yellow solid. MS: m/z=442.7 (M+1, ESI+).

Provenance & Evidence