HCID 67247370, compound → 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)indolizine-8-carboxamide

HRID 1037096Notes

Reaction equation

HRID 1037096 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:26]([F:29])([F:28])[F:27])[O:13][N:12]=[C:11]([C:14]3[N:15]4[C:19]([C:20]([C:23]([OH:25])=O)=[CH:21][CH:22]=3)=[CH:18][CH:17]=[CH:16]4)[CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH2:30][CH2:31][C:32]1[CH:33]=[CH:34][C:35]2[CH2:39][O:38][B:37]([OH:40])[C:36]=2[CH:41]=1>>[Cl:8][C:6]1[CH:5]=[C:4]([C:9]2([C:26]([F:28])([F:29])[F:27])[O:13][N:12]=[C:11]([C:14]3[N:15]4[C:19]([C:20]([C:23]([NH:30][CH2:31][C:32]5[CH:33]=[CH:34][C:35]6[CH2:39][O:38][B:37]([OH:40])[C:36]=6[CH:41]=5)=[O:25])=[CH:21][CH:22]=3)=[CH:18][CH:17]=[CH:16]4)[CH2:10]2)[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 67247370HCID 67247370, compoundHCID 682815336-(aminomethyl)benzo[c][1,2]oxaborol-1(3H)-ol

Product 1

HCID 715765275-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)indolizine-8-carboxamide

Procedure

The title compound can be prepared from 5-(5-(3,5-dichlorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid and 6-(aminomethyl)benzo[c][1,2]oxaborol-1(3H)-ol as shown by the following scheme:

Sources & evidence

ORD record
ord-8f69614d308b45718a76ac82dd6963b2
Source dataset
uspto-grants-2013_10
Patent number
US08546357B2

Reaction notes

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