3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030599, compound

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Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (35 mg, 0.072 mmol) was reacted to give the title compound (22 mg, 79%). LCMS (Method F): RT=9.24 min, [M+H]+=386. 1H NMR (400 MHz, CDCl3): δ 8.01 (d, J=8.6 Hz, 1H), 7.49-7.29 (m, 7H), 7.26 (d, J=8.1 Hz, 2H), 7.17 (d, J=8.1 Hz, 2H), 2.58-2.48 (m, 2H), 2.24-1.97 (m, 3H), 1.79-1.68 (m, 1H).

Provenance & Evidence