{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → (1-[4-(5-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl)-carbamic acid tert-butyl ester

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Reaction Steps

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 5-fluoro-3-iodo-2-phenyl-chromen-4-one (55 mg, 0.15 mmol) was reacted to give the title compound (19 mg, 26%). 1H NMR (400 MHz, CDCl3): δ 7.65-7.57 (m, 1H), 7.41-7.29 (m, 6H), 7.28-7.22 (m, 2H), 7.21-7.16 (m, 2H), 7.09-7.03 (m, 1H), 5.03 (s, 1H), 2.61-2.29 (m, 4H), 2.21-2.00 (m, 1H), 1.88-1.74 (m, 1H), 1.48-1.18 (m, 9H).

Provenance & Evidence