3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-5-fluoro-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(5-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (19 mg, 0.039 mmol) was reacted to give the title compound (11 mg, 73%). LCMS (Method F): RT=8.60 min, [M+H]+=386. 1H NMR (400 MHz, CDCl3): δ 7.63-7.54 (m, 1H), 7.38-7.27 (m, 6H), 7.27-7.20 (m, 2H), 7.15 (d, J=8.6 Hz, 2H), 7.03 (t, J=8.6 Hz, 1H), 2.57-2.47 (m, 2H), 2.24-2.12 (m, 2H), 2.12-1.99 (m, 1H), 1.78-1.66 (m, 1H).

Provenance & Evidence