3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-7,8-dimethoxy-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7,8-dimethoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (41 mg, 0.078 mmol) was reacted to give the title compound (27 mg, 82%). LCMS (Method E): RT=3.55 min, [M+H]+=428. 1H NMR (400 MHz, DMSO-d6): δ 7.79 (d, J=9.2 Hz, 1H), 7.40-7.24 (m, 8H), 7.06 (d, J=8.8 Hz, 2H), 3.93 (s, 3H), 3.86 (s, 3H), 2.36-2.17 (m, 4H), 2.07-1.87 (m, 3H), 1.64-1.53 (m, 1H).

Provenance & Evidence