3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030602, compound

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Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(6-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (42 mg, 0.084 mmol) was reacted to give the title compound (27 mg, 82%). LCMS (Method E): RT=3.70 min, [M+H]+=399. 1H NMR (400 MHz, DMSO-d6): δ 7.65 (d, J=8.7 Hz, 1H), 7.44-7.25 (m, 9H), 7.09-7.04 (m, 2H), 7.83 (s, 3H), 2.35-2.26 (m, 2H), 2.17 (bs, 2H), 2.06-1.87 (m, 3H), 1.64-1.53 (m, 1H).

Provenance & Evidence