3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-7-methoxy-6-methyl-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-methoxy-6-methyl-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (46 mg, 0.090 mmol) was reacted to give the title compound (34 mg, 92%). LCMS (Method E): RT=3.85 min, [M+H]+=412. 1H NMR (400 MHz, DMSO-d6): δ 7.80 (s, 1H), 7.38-7.25 (m, 7H), 7.18 (s, 1H), 7.05 (d, J=9.6 Hz, 2H), 3.90 (s, 3H), 2.35-2.26 (m, 2H), 2.25-2.10 (m, 5H), 2.06-1.87 (m, 3H), 1.64-1.53 (m, 1H).

Provenance & Evidence