3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030691, compound

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Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-oxo-6-phenyl-2,3-dihydro-8H-1,4,5-trioxa-anthracen-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (65 mg, 0.124 mmol) was reacted to give the title compound (27 mg, 51%). LCMS (Method E): RT=3.62 min, [M+H]+=426. 1H NMR (400 MHz, DMSO-d6): δ 7.38 (s, 1H), 7.36-7.23 (m, 7H), 7.19 (s, 1H), 7.04 (d, J=8.6 Hz, 2H), 4.39-4.34 (m, 2H), 4.33-4.28 (m, 2H), 2.36-2.13 (m, 4H), 2.06-1.87 (m, 3H), 1.64-1.53 (m, 1H).

Provenance & Evidence