{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → {1-[4-(8-Bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Participants

Reaction Steps

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 8-bromo-3-iodo-7-methoxy-2-phenyl-chromen-4-one (198 mg, 0.434 mmol) was reacted to give the title compound (100 mg, 40%). 1H NMR (400 MHz, CDCl3): δ 8.27-8.22 (d, 1H), 7.53-7.19 (m, 9H), 7.08-7.03 (d, 1H), 5.06 (s, 1H), 4.06 (s, 3H), 2.58-1.76 (m, 6H), 1.46-1.18 (m, 9H).

Provenance & Evidence