3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-8-bromo-7-methoxy-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (20 mg, 0.035 mmol) was reacted to give the title compound (13 mg, 78%). LCMS (Method E): RT=3.93 min, [M+H]+=476/478. 1H NMR (400 MHz, DMSO-d6): δ 8.05 (d, J=8.7 Hz, 1H), 7.42-7.26 (m, 8H), 7.09 (d, J=7.8 Hz, 2H), 3.99 (s, 3H), 2.56 (bs, 2H), 2.37-2.25 (m, 2H), 2.10-1.87 (m, 3H), 1.66-1.53 (m, 1H).

Provenance & Evidence