3-[4-(1-amino-cyclobutyl)-phenyl]-4-oxo-2-phenyl-4H-chromene-7-carboxylic acid amide → {1-[4-(6-Carbamoyl-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butylester

Participants

Role	Name	HCID	Charge
Reactant	3-[4-(1-amino-cyclobutyl)-phenyl]-4-oxo-2-phenyl-4H-chromene-7-carboxylic acid amide	HCID 51030971	—
Reactant	{1-[4-(6-bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 67067774	—
Product	{1-[4-(6-Carbamoyl-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butylester	HCID 67067752	37%

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-4-oxo-2-phenyl-4H-chromene-7-carboxylic acid amide, {1-[4-(6-bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (115 mg, 0.20 mmol) was reacted to give the title compound (40 mg, 37%). LCMS (Method B): RT=4.58 min, [M+H]+=541.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08546376B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-06cd106ae870477abeeedc7b5ad3b0b3
Source note	uspto-grants-2013_10