3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-7-methoxy-4-oxo-2-phenyl-4H-chromene-6-carboxylic acid amide

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(6-carbamoyl-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butylester (40 mg, 0.074 mmol) was reacted to give the title compound (19 mg, 58%). LCMS (Method E): RT=3.15 min, [M+H]+=441. 1H NMR (400 MHz, DMSO-d6): δ 8.44 (s, 1H), 7.68 (d, J=7.7 Hz, 2H), 7.41-7.26 (m, 8H), 7.10 (d, J=8.3 Hz, 2H), 3.98 (s, 3H), 3.27 (s, 2H), 2.39-2.29 (m, 2H), 2.11-2.02 (m, 2H), 2.00-1.89 (m, 1H), 1.67-1.55 (m, 1H).

Provenance & Evidence