{1-[4-(6-cyano-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → {1-[4-(6-Cyano-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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Reaction Steps

Following the procedure used to prepare {1-[4-(6-cyano-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, {1-[4-(6-bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (115 mg, 0.20 mmol) was reacted to give the title compound (81 mg, 77%). 1H NMR (400 MHz, CDCl3): δ 8.53 (s, 1H), 7.45-7.14 (m, 9H), 7.00 (s, 1H), 5.05 (s, 1H), 4.05 (s, 3H), 2.60-2.39 (m, 4H), 2.16-2.00 (m, 1H), 1.92-1.77 (m, 1H), 1.56-1.14 (m, 9H).

Provenance & Evidence