{1-[4-(6-cyano-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → (1-[4-(8-Cyano-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl)-carbamic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	{1-[4-(6-cyano-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 67067657	—
Reactant	{1-[4-(8-Bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 67067708	—
Product	(1-[4-(8-Cyano-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl)-carbamic acid tert-butyl ester	HCID 67067666	33%

Reaction Steps

Following the procedure used to prepare {1-[4-(6-cyano-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, {1-[4-(8-bromo-7-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (150 mg, 0.0867 mmol) was reacted to give the title compound (15 mg, 33%). LCMS (Method B): RT=4.79 min, [M+H]+=523.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08546376B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-dbc6c30214ed45828ddc4416547a9f92
Source note	uspto-grants-2013_10