3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7-bromo-chromen-4-one

Participants

Reaction Steps

3-[4-(1-Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a pale yellow solid (22 mg, 77%). 1H NMR (400 MHz, DMSO-d6): δ 8.09 (d, J=2 Hz, 1H), 8.03 (d, J=8 Hz, 1H), 7.71 (dd, J=2 and 8 Hz, 1H), 7.45-31 (m, 7H), 7.15-7.11 (m, 2H), 2.40-2.32 (m, 2H), 2.12-2.04 (m, 2H), 2.04-1.94 (m, 1H), 1.69-1.60 (m, 1H). LCMS (Method F): RT=10.10 min, [M+H]+=446/448.

Provenance & Evidence