3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030792, compound

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(6,7-dimethoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (48 mg, 94%). 1H NMR (400 MHz, DMSO-d6): δ 7.42-7.29 (m, 9H), 7.13-7.09 (m, 2H), 3.93 (s, 3H), 3.88 (s, 3H), 2.40-2.33 (m, 2H), 2.11-2.02 (m, 2H), 2.02-1.95 (m, 1H), 1.69-1.60 (m, 1H). LCMS (Method F): RT=8.99 min, [M+H]+=428.

Provenance & Evidence